Question #20 explained
Which of the following is an option for treating Gram positive anaerobe Clostridioides [formerly Clostridium] difficile?
A. Metronidazole – CORRECT (although it has largely fallen out of favor, see IDSA C. difficile guidelines)
B. Clindamycin – INCORRECT: this drug is one of the most common to be implicated in causing C. difficile infection. It’s potent anti-anaerobic activity kills off the bacteria C. difficile competes with, but not C. difficile, thus creating the opportunity for C. difficile to proliferate and cause infection.
C. Vancomycin (oral route) – CORRECT
D. Vancomycin (IV route) – INCORRECT: while vancomycin oral is not well absorbed and stays in the gut to work on where C. difficile is causing infection, the IV route vancomycin will not get to there and will not treat it.
E. Fidaxomicin – CORRECT