Question #3 Explanation:
The addition of a beta-lactamase inhibitor (i.e., clavulanic acid or sulbactam) to an aminopenicillin (i.e., ampicillin or amoxicillin) will add coverage for which organisms?
A. Methicillin-susceptible Staphylococcus aureus (MSSA) – CORRECT
- Ampicillin or amoxicillin alone will not cover MSSA unless it is penicillin sensitive MSSA and that is extremely uncommon
B. Methicillin-resistant Staphylococcus aureus (MRSA)
- The only beta-lactam in the United States with MRSA activity is ceftaroline (Teflaro)
C. Bacteroides fragilis – CORRECT
- The addition of the beta-lactamase inhibitor expands anaerobic coverage significantly
D. Lysteria monocytogenes
- Aminopenicillins like ampicillin and amoxicillin do not require a beta-lactamase inhibitor to cover this Gram positive rod
