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Sample: Bugs and Drugs Practice Test

April 1, 2017 By Admin

Question #3 Explanation:

The addition of a beta-lactamase inhibitor (i.e., clavulanic acid or sulbactam) to an aminopenicillin (i.e., ampicillin or amoxicillin) will add coverage for which organisms?

A. Methicillin-susceptible Staphylococcus aureus (MSSA) – CORRECT

  • Ampicillin or amoxicillin alone will not cover MSSA unless it is penicillin sensitive MSSA and that is extremely uncommon

B. Methicillin-resistant Staphylococcus aureus (MRSA)

  • The only beta-lactam in the United States with MRSA activity is ceftaroline (Teflaro)

C. Bacteroides fragilis – CORRECT

  • The addition of the beta-lactamase inhibitor expands anaerobic coverage significantly

D. Lysteria monocytogenes

  • Aminopenicillins like ampicillin and amoxicillin do not require a beta-lactamase inhibitor to cover this Gram positive rod

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